Bone marrow analysis

Author(s): S. Fruehauf, A. Pitkus
Institution(s): Heidelberg University Medical Centre
Last change of this image collection: 2005/10/29

Comment on this image collection: Bone marrow analysis performed at our institution indicated that the patient has a hypercellular marrow for his or her age. Megakaryopoiesis, is reduced, while erythropoieis and granulopoeisis are significantly reduced. The marrow contains a high-grade infiltrate of approximately 70% myeloblasts. The findings are compatible with an acute myeloid leukemia of the M4 or M5 subtype.
Bone marrow analysis performed at the outside institution showed the presence of a clearly increased blast population. These blasts are medium sized cells containing a round-oval nucleus, close chromatin, rare fine granules, and moderate cytoplasm. Granulopoiesis was less than 20% with clearly dysplastic changes. The Neutrophils are hypogranuluar to agranular with pseudopods. Erthropoiesis is increased with megaloblastoid changes, while megakaryopoiesis is increased with a sigle nucleus and hypolobulated forms. These findings are indicative of an acute monoblastic leukemia, an acute myeloid leukemia of the M5a subtype.

Differential diagnosis: Acute myeloid leukemia of the M5 subtype

Low power microscopy

Low power microscopy