Bone marrow analysis and cytochemical staining

Author(s): S. Fruehauf, A. Pitkus, J. Dengler, S. Kraeker
Institution(s): Heidelberg University Medical Centre
Last change of this image collection: 2007/04/27

Comment on this image collection: Rare megakaryopoiesis, erythropoiesis, and granulopoiesis. The marrow cellularity is substantially increased for the patient's age. There is a high-grade infiltrate of myeloid blasts in the marrow. These cells have a prominent nucleolus and some have nuclei with slight folding and a few have granulation. Cytochemical staining with Sudan Black B (SBB) was positive, while Non-Specific Esterase (NSE) and Periodic Acid Schiff (PAS) are negative. The cytochemical staining results suggest an acute myeoid leukemia of M2 subtype.