AML M5b FAB: Acute monocytic leukemia with predominantly promonocytes - case report 1
Author(s): S. Fruehauf, A. Pitkus, J. Dengler, S. Kraeker
Last change:
2004/08/19
Sort of case report: In clinical view
Medical history: The patient presented with complaints of chest pain and a rash across his back and shoulders persisting for the last 3 days.
Clinical Examination: A routine complete blood count (CBC) was ordered as part of the clinical investigation with the results below. It was found that the patient had an initial leukocytosis. A bone marrow aspirate was ordered for further investigation of the leukocytosis.
Laboratory results:
Parameter
|
Value
|
Normal value [unit]
|
|---|
RBC
|
4.6
|
4.3-6.1 /pl
|
Hemoglobin
|
13.1
|
13.-17. g/dl
|
Hematocrit
|
0.39
|
0.38-0.52 l/l
|
MCV
|
86
|
83-97 fl
|
Plt
|
46
|
150-440 /nl
|
WBC
|
48.31
|
4.0-10.0 /nl
|
Neutrophils
|
14.01
|
1.8-7.7 /nl
|
Lymphocytes
|
9.66
|
1.0-4.8 /nl
|
Monocytes
|
2.42
|
0.2-0.8 /nl
|
Eosinophils
| |
0-0.5 /nl
|
| | | |
Differential
|
Results
| |
Band Neutrophils
|
3
|
3-10 %
|
Segmented Neutrophils
|
26
|
50-70 %
|
Lymphocytes
|
20
|
25-40 %
|
atypical Lymphs
|
22
|
%
|
Monocytes
|
5
|
2-9 %
|
Eosinophils
| |
2-4 %
|
Basophils
| |
0-1 %
|
Metamyelocytes
|
4
|
0 %
|
Myelocytes
| |
%
|
Promyelocytes
| |
%
|
Blasts
|
20
|
0 %
|
Normoblasts
| |
/ 100 L
|
| | | |
Bone Marrow
|
Differential
|
Results
|
Red Cell Precursors
|
10 %
| |
Band Neutrophils
|
2 %
| |
Segmented Neutrophils
|
4 %
| |
Eosinophils
|
2 %
| |
Blasts
|
90 %
| |
Juveniles
|
2 %
| |
Cytogenetics: No cytogenetics testing was performed on this patient.
Molecular genetics (incl. Southern blot, PCR): No Molecular Diagnostic testing was performed.
Diagnosis: Although the Immunophenotyping is suggestive of a Chronic Myelomonocytic Leukemia, the cytology results are indicative of an acute myeloid leukemia of the M5b subtype.
Differential diagnosis: Chronic Myelomonocytic Leukemia (CMML)
Hematologic Disorders
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